Scientists shed new light on link between 'killer cells' and diabetes (UK)

Killer T-cells in the human body which help protect us from disease can inadvertently destroy cells that produce insulin, new research has uncovered. The study provides the first evidence of this mechanism in action and could offer new understanding of the cause of Type 1 diabetes. Professor Andy Sewell, an expert in human T-cells from Cardiff University's School of Medicine worked alongside diabetes experts from King's College London to better understand the role of T-cells in the development of Type 1 diabetes. The team isolated a T-cell from a patient with Type 1 diabetes to view a unique molecular interaction which results in the killing of insulin-producing cells in the pancreas. "Type 1 diabetes is a result of the body's own immune system attacking and destroying the cells in the pancreas that manufacture the hormone insulin. Insulin controls blood sugar levels and a lack of insulin is fatal if untreated," said Professor Sewell. The study, funded by the UK Biotechnology and Biological Sciences Research Council, the Juvenile Diabetes Research Foundation using facilities at Diamond Light Source and published in Nature Immunology, shows that the killer T-cell receptor utilises an abnormal mode of binding in order to recognise cells producing insulin