New research links genetic variant, poor glycemic control to coronary artery disease

"A new study led by researchers at the Joslin Diabetes Center and Harvard Medical School has found that a common genetic variant associated with an increased risk of coronary artery disease in the general population is also linked to an even higher risk for people with diabetes, particularly those with poor glucose control. The study, published in the November 26 issue of the Journal of the American Medical Association, is the first to find the additional increased risk of coronary artery disease in those with diabetes who have the genetic flaw on chromosome 9p21. Those with two copies of the variant coupled with poor glycemic control experienced a four-fold increased risk for CAD relative to those without the variant and in good glycemic control" - PhysOrg.com